Thin endometrium is a silent hurdle that makes it difficult for women to conceive. It causes repeated setbacks in their fertility journey. But hey, don’t you lose hope because science has been making it easy to reach the dreams of motherhood. Recently, PRP and stem cell therapy have emerged as advanced, promising solutions for dealing with thin endometrium.
There are early clinical experiences showing encouraging outcomes. At Apex Hospital, this progress isn’t just being followed but being actively explored. Dr. Manisha Mehta – leading obstetrician and gynaecologist – has begun focused research into PRP and mesenchymal stem cell application for endometrial regeneration.
In this blog, Apex Hospital – home to experienced infertility doctors in India – will walk you through everything you need to understand about PRP + stem cells treatment, learning how doctors are working to offer a ray of light to women not just in India but also in other countries.
Let’s start.
What is Thin Endometrium?
Before addressing the elephant in the room, we should learn the basics. Because of a lack of clarity, your fertility challenges will remain confusing and frustrating. Thin endometrium is a condition where the uterine lining (endometrium) becomes thinner than the required lining for supporting embryo implantation and pregnancy.
Under normal conditions, the endometrium thickens during the menstrual cycle, preparing to receive and nourish a fertilized egg. But factors like hormonal disequilibrium, surgical uterine operations, infections, poor blood flow, and aging can make the lining chronically thin.
This makes it difficult for women to conceive. It also results in failed IVF cycles and increases risk of miscarriage. Ladies with a thin endometrium may experience irregular periods or no symptoms at all. Making a diagnosis is a big challenge.
What Are the Causes of Thin Endometrium?
We have already mentioned some causes of thin endometrium. But hey, it makes more sense to explore them in greater detail and understand why such a condition develops. After all, knowing the root causes will make diagnosis and treatment more effective.
Here are the main causes of thin endometrium in women:
Hormonal imbalance: Estrogen helps to thicken the endometrium during the menstrual cycle. Having low levels in your body simply means hormonal disorders. The lining may not develop normally.
Uterine surgery or procedures: Surgeries like dilation and curettage (D&C), cesarean sections, and removal of fibroids may cause scarring (Asherman syndrome) which results in a thin or damaged endometrium.
Infections: Inflammation and injury to the uterine lining can also be caused by pelvic infection or untreated sexually transmitted infections (STIs).
Poor blood flow: Yes, it’s true! Endometrial growth can be hampered by lower blood flow in the uterus. Wondering what could cause that? It can be a result of conditions like diabetes, hypertension, and vascular problems.
Age-related factors: As women age, particularly when they hit 35 years, their endometrium might thin on its own. This can affect their fertility.
Medications: Certain medications that you’ve been using (say, fertility treatment drugs) can also hurt the endometrial thickness.
Lifestyle Factors: Smoking, excessive stress, and poor nutrition can also influence the well being of your endometrium.
How PRP and Stem Cell Therapy Help With Thin Endometrium?
Time to put the spotlight on two superior therapies that are gaining recognition as a possible solution to thin endometrium! PRP therapy involves using a highly concentrated level of the patient’s own blood platelets. Since these are rich in growth factors, they can repair and regenerate tissues.
Upon being introduced to the uterus, PRP triggers the endometrial lining to become thicker and healthier. Enhancing its readiness to support embryo implantation. Stem cell therapy, in contrast, uses specialized cells capable of changing other types of tissues.
Known for having amazing regenerative abilities, stem cells, when used on the endometrium, promote the development of new, healthy tissue. They repair damaged areas and promote blood flow. This creates a receptive atmosphere for pregnancy.
Don’t forget to check out these resources as well:
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Everything about IVF in India
Learn about ICSI and its differences from IVF
Can PRP and Stem Cell Therapy Be Combined For Thin Endometrium Treatment?
Yes, PRP (platelet-rich plasma) and stem cell therapy can be combined to treat thin endometrium. This combination is becoming well-known due to its high regenerative capacity! Although both therapies separately have profound advantages in stimulating endometrial growth and repair, combining them can provide a potent synergy that optimizes the healing environment of the uterine lining.
And no, we are not saying it generally. Clinical and preclinical data are mounting in support of PRP and stem cell-based therapies for thin endometrium. Early evidence is accumulating regarding their combination. A 2021 case report from National Library of Medicine suggested successful treatment of refractory thin endometrium with a combination of autologous bone marrow-derived stem cells (ABMDSCs) and PRP that resulted in sufficient lining and pregnancy. Emphasizing the importance of growth factors in combination with regenerative cells.
A systematic review and clinical series were also carried out on 51 patients with heterogeneous infertility. They demonstrated how intrauterine PRP enhanced endometrial thickness and clinical pregnancy rate in a thin endometrium and recurrent implantation failure. Throughout the series, growth factors were witnessed stimulating angiogenesis and proliferation.
Then we have a meta-analysis of eight RCTs (678 patients) published in 2024. It concluded that PRP significantly increased endometrial thickness, clinical pregnancy, live birth, and implantation rates compared to controls. Supporting PRP as a useful adjunct when the lining is thin.
Although it’s true that evidence of PRP alone is growing, there’s still limited high-quality research specifically on combined use of PRP and stem cell therapy for treating thin endometrium in females. This means conclusions should be cautious and framed within ongoing research.
How PRP and Stem Cell Therapy Are Expected to Work?
Starting with PRP, well, it’s a rich source of growth factors that accelerate tissue healing, cell proliferation, and blood circulation. It offers best regeneration environment. Stem Cell Therapy complements this by introducing versatile cells that would turn into healthy endometrial tissue and repair the damaged regions.
PRP acts as an organic fertilizer, stimulating functions and survival of stem cells to renew the uterine lining more effectively and efficiently. This two-pronged therapy has a quicker and more effective response, particularly to women who did not respond well to conventional treatments or either therapy alone. It will work on multiple fronts.
What Apex Hospital Has to Say on PRP + Stem Cell Therapy for Thin Endometrium?
The vision of Apex Hospital in Sirsa, Haryana, is straightforward – turn science into second chances. Dr. Manisha Mehta – top gynecologist and infertility specialist in India – sees PRP and mesenchymal stem cell-based treatments as a next step in the treatment of women whose endometrium has failed to respond to traditional approaches.
She has also embarked on a step-by-step, independent research program to study safety, dosing, timing, and patient selection- since meaningful breakthroughs require patience, data and transparency.
“This is not a race but a slow marathon with the aim of serving the women in India and the whole world.”, she said when asked about it.
Progress, in her words and practice ethos, is constructed on two pillars – cautious optimism and rigorous follow-up. PRP may help wake up repair pathways and micro-circulation; stem cells could be used to stimulate tissue-repair and receptivity.
Together, the hope is a more receptive, more powerful lining of those who have suffered frequent failures. But again, research must lead the way. They can take months to mature. Dr. Manisha feels that protocols must be streamlined and all the success stories must be recorded to guide the next patient through his or her own journey.
For patients, this translates to having compassionate counseling today and being able to make smarter and more personal choices tomorrow. Should this long road be all it now promises, it might be a win-win. A new breath of hope for families, a prudently constructed passage to universal care.
PRP + Stem Cells Therapy: Final Words
Above is everything you need to know about undergoing PRP and stem cells therapy for regenerating and restoring a healthy uterine lining. We hope you now understand how much these innovative treatments can improve the fertility journey of those who are struggling with thin endometrium.
If you’re someone living in Sirsa, Haryana or in nearby areas and facing infertility challenges, Apex Hospital is here to provide expert guidance and personalized treatment plans. With cutting-edge technology, compassionate care, and an experienced team of gynaecologists, we offer renewed hope and real possibilities of motherhood.
Call us at (+91) 91680-39000 or (+91) 96196-42000 to book an appointment.
